The aetiology, origins, and diagnosis of severe acute respiratory syndrome
Identifieur interne : 005027 ( Main/Exploration ); précédent : 005026; suivant : 005028The aetiology, origins, and diagnosis of severe acute respiratory syndrome
Auteurs : Llm Poon [République populaire de Chine] ; Y. Guan [République populaire de Chine] ; Jm Nicholls [République populaire de Chine] ; Ky Yuen [République populaire de Chine] ; Jsm Peiris [République populaire de Chine]Source :
- The Lancet. Infectious Diseases [ 1473-3099 ] ; 2004.
Descripteurs français
- KwdFr :
- ARN viral (analyse), Animaux, Chine (épidémiologie), Flambées de maladies, Génome viral, Humains, Maladies transmissibles émergentes, Phylogénie, RT-PCR, Réservoirs d'agents pathogènes, Syndrome respiratoire aigu sévère (), Syndrome respiratoire aigu sévère (diagnostic), Syndrome respiratoire aigu sévère (transmission), Syndrome respiratoire aigu sévère (virologie), Syndrome respiratoire aigu sévère (épidémiologie), Virus du SRAS (génétique).
- MESH :
- analyse : ARN viral.
- diagnostic : Syndrome respiratoire aigu sévère.
- génétique : Virus du SRAS.
- virologie : Syndrome respiratoire aigu sévère.
- épidémiologie : Chine, Syndrome respiratoire aigu sévère.
- Animaux, Flambées de maladies, Génome viral, Humains, Maladies transmissibles émergentes, Phylogénie, RT-PCR, Réservoirs d'agents pathogènes, Syndrome respiratoire aigu sévère.
- Wicri :
- geographic : République populaire de Chine.
English descriptors
- KwdEn :
- Animals, China (epidemiology), Communicable Diseases, Emerging, Disease Outbreaks, Disease Reservoirs, Genome, Viral, Humans, Phylogeny, RNA, Viral (analysis), Reverse Transcriptase Polymerase Chain Reaction, SARS Virus (genetics), Severe Acute Respiratory Syndrome (diagnosis), Severe Acute Respiratory Syndrome (epidemiology), Severe Acute Respiratory Syndrome (prevention & control), Severe Acute Respiratory Syndrome (transmission), Severe Acute Respiratory Syndrome (virology).
- MESH :
- chemical , analysis : RNA, Viral.
- geographic , epidemiology : China.
- diagnosis : Severe Acute Respiratory Syndrome.
- epidemiology : Severe Acute Respiratory Syndrome.
- genetics : SARS Virus.
- prevention & control : Severe Acute Respiratory Syndrome.
- transmission : Severe Acute Respiratory Syndrome.
- virology : Severe Acute Respiratory Syndrome.
- Animals, Communicable Diseases, Emerging, Disease Outbreaks, Disease Reservoirs, Genome, Viral, Humans, Phylogeny, Reverse Transcriptase Polymerase Chain Reaction.
Abstract
Severe acute respiratory syndrome (SARS) is a new infectious disease that first emerged in Guangdong province, China, in November, 2002. A novel coronavirus was later identified in patients with SARS. The detection of the virus in these patients, its absence in healthy controls or other patients with atypical pneumonia, and the reproduction of a similar disease in a relevant animal model fulfilled Koch's postulates for implicating this coronavirus as the causal agent of SARS. The full genome sequence was determined within weeks of the virus's identification. The rapid progress in the aetiology, the development of laboratory diagnostic tests, and the defining of routes of viral transmission were facilitated through a unique WHO-coordinated virtual network of laboratories, which shared information on a real-time basis through daily teleconferences. Subsequent studies have indicated that the SARS coronavirus is of animal origin, that its precursor is still present in animal populations within the region, and that live-animal markets in southern China may have provided the animal-human interphase that allowed this precursor virus to adapt to human-human transmission. These findings underscore the potential for the re-emergence of SARS and the need for laboratory tests for early diagnosis. However, the low viral load in the respiratory tract makes early diagnosis of SARS a diagnostic challenge, although improvements in the sensitivity of molecular diagnostic methods continue to be made.
Url:
DOI: 10.1016/S1473-3099(04)01172-7
PubMed: 15522678
PubMed Central: 7106534
Affiliations:
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Guan</name><affiliation wicri:level="1"><nlm:aff id="aff1">Department of Microbiology, University of Hong Kong, Hong Kong SAR, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Microbiology, University of Hong Kong, Hong Kong SAR</wicri:regionArea><wicri:noRegion>Hong Kong SAR</wicri:noRegion></affiliation></author><author><name sortKey="Nicholls, Jm" sort="Nicholls, Jm" uniqKey="Nicholls J" first="Jm" last="Nicholls">Jm Nicholls</name><affiliation wicri:level="1"><nlm:aff id="aff2">Department of Pathology, University of Hong Kong, Hong Kong SAR, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Pathology, University of Hong Kong, Hong Kong SAR</wicri:regionArea><wicri:noRegion>Hong Kong SAR</wicri:noRegion></affiliation></author><author><name sortKey="Yuen, Ky" sort="Yuen, Ky" uniqKey="Yuen K" first="Ky" last="Yuen">Ky Yuen</name><affiliation wicri:level="1"><nlm:aff id="aff1">Department of Microbiology, University of Hong Kong, Hong Kong SAR, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Microbiology, University of Hong Kong, Hong Kong SAR</wicri:regionArea><wicri:noRegion>Hong Kong SAR</wicri:noRegion></affiliation></author><author><name sortKey="Peiris, Jsm" sort="Peiris, Jsm" uniqKey="Peiris J" first="Jsm" last="Peiris">Jsm Peiris</name><affiliation wicri:level="1"><nlm:aff id="aff1">Department of Microbiology, University of Hong Kong, Hong Kong SAR, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Microbiology, University of Hong Kong, Hong Kong SAR</wicri:regionArea><wicri:noRegion>Hong Kong SAR</wicri:noRegion></affiliation></author></analytic><series><title level="j">The Lancet. Infectious Diseases</title><idno type="ISSN">1473-3099</idno><idno type="eISSN">1474-4457</idno><imprint><date when="2004">2004</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>China (epidemiology)</term><term>Communicable Diseases, Emerging</term><term>Disease Outbreaks</term><term>Disease Reservoirs</term><term>Genome, Viral</term><term>Humans</term><term>Phylogeny</term><term>RNA, Viral (analysis)</term><term>Reverse Transcriptase Polymerase Chain Reaction</term><term>SARS Virus (genetics)</term><term>Severe Acute Respiratory Syndrome (diagnosis)</term><term>Severe Acute Respiratory Syndrome (epidemiology)</term><term>Severe Acute Respiratory Syndrome (prevention & control)</term><term>Severe Acute Respiratory Syndrome (transmission)</term><term>Severe Acute Respiratory Syndrome (virology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>ARN viral (analyse)</term><term>Animaux</term><term>Chine (épidémiologie)</term><term>Flambées de maladies</term><term>Génome viral</term><term>Humains</term><term>Maladies transmissibles émergentes</term><term>Phylogénie</term><term>RT-PCR</term><term>Réservoirs d'agents pathogènes</term><term>Syndrome respiratoire aigu sévère ()</term><term>Syndrome respiratoire aigu sévère (diagnostic)</term><term>Syndrome respiratoire aigu sévère (transmission)</term><term>Syndrome respiratoire aigu sévère (virologie)</term><term>Syndrome respiratoire aigu sévère (épidémiologie)</term><term>Virus du SRAS (génétique)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>RNA, Viral</term></keywords><keywords scheme="MESH" type="geographic" qualifier="epidemiology" xml:lang="en"><term>China</term></keywords><keywords scheme="MESH" qualifier="analyse" xml:lang="fr"><term>ARN viral</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Severe Acute Respiratory Syndrome</term></keywords><keywords scheme="MESH" qualifier="diagnostic" xml:lang="fr"><term>Syndrome respiratoire aigu sévère</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Severe Acute Respiratory Syndrome</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>SARS Virus</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Virus du SRAS</term></keywords><keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Severe Acute Respiratory Syndrome</term></keywords><keywords scheme="MESH" qualifier="transmission" xml:lang="en"><term>Severe Acute Respiratory Syndrome</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Syndrome respiratoire aigu sévère</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Severe Acute Respiratory Syndrome</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Chine</term><term>Syndrome respiratoire aigu sévère</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Communicable Diseases, Emerging</term><term>Disease Outbreaks</term><term>Disease Reservoirs</term><term>Genome, Viral</term><term>Humans</term><term>Phylogeny</term><term>Reverse Transcriptase Polymerase Chain Reaction</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Flambées de maladies</term><term>Génome viral</term><term>Humains</term><term>Maladies transmissibles émergentes</term><term>Phylogénie</term><term>RT-PCR</term><term>Réservoirs d'agents pathogènes</term><term>Syndrome respiratoire aigu sévère</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>République populaire de Chine</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>Summary</title><p>Severe acute respiratory syndrome (SARS) is a new infectious disease that first emerged in Guangdong province, China, in November, 2002. A novel coronavirus was later identified in patients with SARS. The detection of the virus in these patients, its absence in healthy controls or other patients with atypical pneumonia, and the reproduction of a similar disease in a relevant animal model fulfilled Koch's postulates for implicating this coronavirus as the causal agent of SARS. The full genome sequence was determined within weeks of the virus's identification. The rapid progress in the aetiology, the development of laboratory diagnostic tests, and the defining of routes of viral transmission were facilitated through a unique WHO-coordinated virtual network of laboratories, which shared information on a real-time basis through daily teleconferences. Subsequent studies have indicated that the SARS coronavirus is of animal origin, that its precursor is still present in animal populations within the region, and that live-animal markets in southern China may have provided the animal-human interphase that allowed this precursor virus to adapt to human-human transmission. These findings underscore the potential for the re-emergence of SARS and the need for laboratory tests for early diagnosis. However, the low viral load in the respiratory tract makes early diagnosis of SARS a diagnostic challenge, although improvements in the sensitivity of molecular diagnostic methods continue to be made.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Fleck, F" uniqKey="Fleck F">F Fleck</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Caulford, P" uniqKey="Caulford P">P Caulford</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Enserink, M" uniqKey="Enserink M">M Enserink</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Heymann, Dl" uniqKey="Heymann D">DL Heymann</name></author><author><name sortKey="Rodier, G" uniqKey="Rodier G">G Rodier</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Breiman, Rf" uniqKey="Breiman R">RF Breiman</name></author><author><name sortKey="Evans, Mr" uniqKey="Evans 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Normile</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>République populaire de Chine</li></country></list><tree><country name="République populaire de Chine"><noRegion><name sortKey="Poon, Llm" sort="Poon, Llm" uniqKey="Poon L" first="Llm" last="Poon">Llm Poon</name></noRegion><name sortKey="Guan, Y" sort="Guan, Y" uniqKey="Guan Y" first="Y" last="Guan">Y. Guan</name><name sortKey="Nicholls, Jm" sort="Nicholls, Jm" uniqKey="Nicholls J" first="Jm" last="Nicholls">Jm Nicholls</name><name sortKey="Peiris, Jsm" sort="Peiris, Jsm" uniqKey="Peiris J" first="Jsm" last="Peiris">Jsm Peiris</name><name sortKey="Yuen, Ky" sort="Yuen, Ky" uniqKey="Yuen K" first="Ky" last="Yuen">Ky Yuen</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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